Nancy Kwan Man

MBBS, MS, PHD

Chair Professor of Transplant Oncology and Immunology

Director, Clinical and Translational Research

Director, The Laboratory for Liver Transplantation and Liver Cancer Research

Director, The Laboratory for Organ Transplantation and Regeneration

Department of Surgery

School of Clinical Medicine

LKS Faculty of Medicine

The University of Hong Kong

Dedicated to enhancing the outcomes of liver transplantation through reducing graft injury and cancer recurrence, Nancy leads research endeavours encompassing basic, clinical, and translational studies resulting in major advances on transplant oncology and immunology in the world. As the top 2% Scientists Worldwide on Stanford List, Nancy has published more than 210 papers in leading international journals with 17000 citations (H index 74). She and her team received numerous international awards including Basic Science Established Investigator Award and Rising Star Awards from International Liver Transplantation Society (ILTS), Mentor/Mentee Awards from The Transplantation Society (TTS), and Scholar in Training Award from American Association for Cancer Research (AACR).  

Nancy and her team have successfully established various clinical, translational and basic research platforms including numerous animal models for liver surgery, transplantation and cancer research, together with a 30 years clinical biobank and database with 100% patients’ follow-up. Recently, they have developed a bionic tumor model with immune environment by 3D/4D bioprinting for the novel theranostics in cancer immunology.  

Section A - Five most representative publications in recent five years (* corresponding author)

1. Liu H, Yeung WH, Pang L, Liu J, Liu XB, Ng KT, Zhang Q, Qiu WQ, Zhu Y, Ding T, Wang Z, Zhu JY, Lo CM, Man K*. Arachidonic acid activates NLRP3 inflammasome in MDSCs via FATP2 to promote post-transplant tumor recurrence in steatotic liver grafts. JHEP Report 2023 Aug https://doi.org/10.1016/j.jhepr.2023.100895.

2. Tan ZW, Chiu MS, Yang XX, Yue M, Cheng TT, Zhou DY, Wang YW, Chan AWH, Yan CW, Wong YC, Ki X, Zhou JJ, To KF, Zhu, JY, Lo CM , Cheng ASL, Liu L, Song YQ, Man K*, Chen ZW*. Isoformic PD-1-mediated Immunosuppression 1 Underlies Resistance to PD-1 Blockade in Hepatocellular Carcinoma Patients. Gut 2023 Aug;72(8):1568-1580. doi: 10.1136/gutjnl-2022-327133. Epub 2022 Nov 30.

3. Liu J, Pang L, Ng KTP, Chiu TL, Liu H, Liu XB, Xu AM, Lo CM, Man K*. Compromised AMPK-PGC1α axis exacerbated steatotic graft injury by dysregulating mitochondrial homeostasis in living donor liver transplantation. Annals of Surgery 2022 Nov 1;276(5):e483-e492.

4. Pang Li, Yeung OWH, Ng KTP, Liu H, Zhu JY, Liu J, Yang XX, Ding T, Qiu WQ, Wang YW, Chiu STL, Chen ZW, Lo CM, Man K*. Postoperative IFN-α-producing plasmacytoid dendritic cells drive hepatocellular carcinoma recurrence via IRF1/CX3CL1-mediated MDSC recruitment. Cancer Research 2022 Nov 15;82(22):4206-4218. doi: 10.1158/0008-5472.CAN-22-1199.

5. Wei T†, Liu J†, Li D†, Chen S, Zhang Y, Li J, Fan L, Guan Z, Lo CM, Wang L*, Man K*, and Sun D*, Development of Magnet-driven and Image-guided Biodegradable Microrobots for the Precise Delivery of Engineered Stem Cells for Cancer Therapy, Small 2020 Oct;16(41):e1906908. doi: 10.1002/smll.201906908.

Section B - Five representative publications during 2010-2016 (* corresponding author)

1. Li CX, Ling CC, Shao Y, Xu A, Li XC, Ng KT, Liu XB, Ma YY, Qi X, Liu H, Liu J, Yeung OW, Yang XX, Liu QS, Lam YF, Zhai Y, Lo CM, Man K*. CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation Journal of Hepatology  2016 Nov;65(5):944-952. doi: 10.1016/j.jhep.2016.05.032.

2. Yeung OW, Lo CM, Ling CC, Qi X, Geng W, Li CX, Ng KT, Forbes SJ, Guan XY, Poon RT, Fan ST, Man K*. Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma. Journal of Hepatology 2015 Mar;62(3):607-16.

3. Ling CC, Ng Kevin TP, Shao Y, Geng W, Xiao JW, Liu XB, Ma YY, Yeung WH, Wong Nathalie, Zhai Y, Chan SC, Poon RTP, Lo CM, Man K*. Post-transplant endothelial progenitor cell mobilization via CXCL10/CXCR3 signaling promotes liver tumor growth. Journal of Hepatolog. 2014 Jan; 60(1):103-9.

4. Li CX, Ng KT, Shao Y, Liu XB, Ling CC, Ma YY, Geng W, Qi X, Cheng Q, Chung SK, Lo CM, Man K*. The inhibition of aldose reductase attenuates hepatic ischemia-reperfusion injury through reducing inflammatory response. Annals of Surgery. 2014 Aug; 260(2):317-28.

5. Man K*, Shih KC, Ng KT, Xiao JW, Guo DY, Sun CK, Lim ZX, Cheng Q, Liu Y, Fan ST, Lo CM.  Molecular signature linked to acute phase injury and tumor invasiveness in small-for-size liver grafts. Annals of Surgery  2010 June; 251 (6): 1154-61. 

Selective awards and honors:

1. “Golden Medal” in International Invention Geneva 2024

2. “CAI Award for Invention and Innovation”, in International Invention Geneva 2024

3. “2022 Basic Science Established Investigator Award of International Liver Transplantation Society”

4. “Rising Star Awards of International Liver Transplantation Society (ILTS)”

Mentee: 2006; Mentor: 2007, 2010, 2011, 2016, 2018, 2020/21 & 2022

5. “American Association of Cancer Research (AACR) Scholar in Training Award”: 2008

6. “The Transplantation Society (TTS) International Basic Science Mentee/Mentor Award”: 2011, 2012, 2013, 2014, 2015, 2016 & 2018

7. “First Class Award of Higher Education Outstanding Scientific Research Output Award” from Ministry of Education: 2013

8.“First Class Award for of Chinese Medical Association” (CAE):  2014       

Editorships

Editorial Board Member of “Annals of Surgery”      since 2018

Editorial Advisory Board Member of “Bioconjugate Chemistry”    since 2018

Deputy Editor of “Transplantation”       since 2015

Editorial Board of “Current Gene Therapy”      since 2014

Editor-in-Chief of “Tribune” – the newsletter of TTS     since 2013

Associate Editor of “Liver Transplantation”       2011-2015

Regional Associate Editor of “Transplantation”      2012-2014

International Academic Society Leaderships

Program Chair of Congress of Asian Society of Transplantation (CAST)   2022-2023

Member of Publication Committee & Sponsorship Committee    Since 2022

Immediate Past President of International Liver Transplantation Society (ILTS)  2019-2021

ILTS President          2018-2019

ILTS President-Elect         2017-2018

ILTS Congress Program Chair         2018

Councilor of ILTS         2015-2017

Member of Publication Committee of ILTS      2015-2017

Member of Education Committee of ILTS      2012-2015

Member of Basic Science Committee of ILTS      2009-2015

Chair of Scholarship Committee of ILTS       2008-2015

Member of Research Grant Committee of The transplantation Society (TTS)  since 2022

Member of Transplant Science Committee of TTS     2014-2020

Founder member of Women Leaders in Transplantation of TTS    since 2009

Key Opinion Leader of TTS        since 2007

Local Professional Society Leaderships

President of Hong Kong Scientist Association (HKSA)      since 2017

Councilor of Hong Kong Society of Immunology (HKSI)     since 2016

President of HKSI             since 2022