Jiandong Huang

1988 B.S., Genetics and Genetic Engineering, Fudan University

1994 Ph.D., Biochemistry, University of California, Los Angeles

1994 Postdoctoral Research Fellow, NCI, NIH, USA,

1998 Assistant Professor, Department of Biochemistry, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China

2006 Associate Professor with Tenure, Department of Biochemistry, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China

2014 Professor, Department of Biochemistry/School of Biomedical Sciences, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China

2015 L & T Charitable Foundation Professor in Biomedical Sciences 慧賢慈善基金教授 (生物醫學), School of Biomedical Sciences, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China

2020 Chair of Synthetic Biology, School of Biomedical Sciences, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China

Prof. Huang's research primarily concentrates on synthetic biology and intracellular transportation. In the field of intracellular transportation, he was the first to report the direct interaction between microtubule- and actin-filament-based transportation systems through their motor proteins, kinesin and myosin. His lab is currently investigating the functions of Kinesin-1, a microtubule-based motor protein, in various cell types and its impact on cellular processes during development and disease.

Notably, Prof. Huang was the first researcher in the greater China region to publish a paper on synthetic biology in Science. In his lab, Prof. Huang develops innovative genetic circuits that regulate gene expression and cell-cell communication. He has collaborated with colleagues to design a genetic circuit capable of controlling cell distribution and function in space and time, which can be used to study the formation and regulation of biological structures. Furthermore, he has engineered interactions among multiple cell types to generate intricate biological structures.

Currently, Prof. Huang's lab employs a synthetic biology approach to create novel vaccines for infectious diseases and cancer treatments. In one of their projects, the Huang Lab programmed bacteria as a tumor therapeutic drug that can effectively suppress cancer metastasis.

1. Jian-Dong Huang, Scott T. Brady, Bruce W. Richards, David Stenoien, James H. Resau, Neal G. Copeland & Nancy A. Jenkins (January, 1999). Direct interaction of microtubule- and actin-based transport motors. Nature, V397: 267-270

2. Baohua Liu, Jianming Wang, Kui Ming Chan, Wai Mui Tjia, Wen Deng, Xinyuan Guan, Jian-Dong Huang, Kai Man Li, Pui Yin Chau, David J Chen, Duanqing Pei, Alberto M Pendas, Juan Cadiñanos, Carlos López-Otín, Hung Fat Tse, Chris Hutchison, Junjie Chen, Yihai Cao, Kathryn S E Cheah, Karl Tryggvason & Zhongjun Zhou (July, 2005). Genomic Instability in Laminopathy-based Premature Aging, Nature Medicine, V11(7): 780-785.

3. Richard Y Kao, Dan Yang, Lai-Shan Lau, Wayne H W Tsui, Lihong Hu, Jun Dai, Mei-Po Chan, Che-Man Chan, Pui Wang, Bo-Jian Zheng, Jian Sun, Jian-Dong Huang, Jason Madar, Guanhua Chen, Honglin Chen, Yi Guan & Kwok-Yung Yuen (2010) Identification of influenza A nucleoprotein as an antiviral target. Nature Biotechnology V28, P600–605

4. Chenli Liu, Xiongfei Fu, Lizhong Liu, Xiaojing Ren, Carlos K.L. Chau, Sihong Li, Lu Xiang, Hualing Zeng, Guanhua Chen, Lei-Han Tang, Peter Lenz, Xiaodong Cui, Wei Huang, Terence Hwa, Jian-Dong Huang (2011) Sequential establishment of stripe patterns in an expanding cell population. Science V334(6053), P238-241.

5. Bao-zhong Zhang, Ye-fan Hu, Lin-lei Chen, Thomas Yau, Yi-gang Tong, Jing-chu Hu, Jian-piao Cai, Kwok-Hung Chan, Ying Dou, Jian Deng, Xiao-lei Wang, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To*, Kwok-yung Yuen, and Jian-Dong Huang (2020) Mining of Epitopes on Spike Protein of SARS-CoV-2 from COVID-19 Patients. Cell Research V30(8) P702-704

6. Bao-zhong Zhang, Hin Chu, Shuo Han, Huiping Shuai, Jian Deng, Ye-fan Hu, Hua-rui Gong, Andrew Chak-Yiu Lee, Zijiao Zou, Thomas Yau, Wutian Wu, Ivan Fan-Ngai Hung, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Jian-Dong Huang (2020) SARS-CoV-2 productively infects human brain organoids. Cell Research V30, P928–931

7. Agnese I. Curatolo, Nan Zhou, Yongfeng Zhao, Chenli Liu, Adrian Daerr, Julien Tailleur and Jian-Dong Huang (2020) Cooperative pattern formation in multi-species bacterial colonies. Nature Physics (article) V16, PP 1152–1157   

8. Qiubin Lin, Li Rong, Xian Jia, Renhao Li, Bin Yu, Jingchu Hu, Xiao Luo, Badea Smaranda-ruxandra, Chen Xu, Guofeng Fu, Kejiong Lai, Ming-chun Lee, Baozhong Zhang, Huarui Gong, Nan Zhou, Xiao Lei Chen, Shu-hai Lin, Guo Fu, Jian-Dong Huang, (2021) “Salmonella potently inhibits cancer metastasis by activating IFN-γ-dependent NK cell”, Nature Communications V12:2537

9. Huiping Shuai, Jasper Fuk-Woo Chan, Bingjie Hu, Yue Chai, Terrence Tsz-Tai Yuen, Feifei Yin, Xiner Huang, Chaemin Yoon, Jing-Chu Hu, Huan Liu, Jialu Shi, Yuanchen Liu, Tianrenzheng Zhu, Jinjin Zhang, Yuxin Hou, Yixin Wang, Lu Lu, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Melinda A. Brindley, Bao-Zhong Zhang, Jian-Dong Huang, Kelvin Kai-Wang To, Kwok-Yung Yuen#, Hin Chu#, (2022) “Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron”, Nature V603, Pages 693–699

10. Ye-Fan Hu†, Terrence Tsz-Tai Yuen†, Hua-Rui Gong†, Bingjie Hu†, Jing-Chu Hu†, Li Rong†, Lin-lei Chen, Xiao-lei Wang, Chaobi Lei, Xuan-Sheng Lin, Thomas Yau, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To, Kwok-Yung Yuen, Bao-Zhong Zhang*, Hin Chu*, Jian-Dong Huang* (Received: January 11, 2023; Revised: June 3, 2023; Accepted: July 7, 2023; Published: July 31, 2023) “Rational design of a booster vaccine strain against COVID-19 based on antigenic distance”, Cell Host & Microbe, V 31, 1–16

Full publication list link:

https://scholar.google.com/citations?user=dFBjCgoAAAAJ&hl=en

1988 Outstanding Graduate Award for Universities in Shanghai

1988 China and United States Biochemistry Examination and Application (CUSBEA) Program

1990 Clorox Foundation Prize

1991 Sigma Xi, Grant-in-Aid of Research Award

1998 NIH Fellows Award for Research Excellence (FARE 1999)

2020 Awardee, Croucher Senior Research Fellowships 2021-2022
裘槎優秀科研者獎

2021 Awardee, WuXi AppTec Life Science and Chemistry Awards
2021 年第十五屆藥明康德生命化學研究獎學者獎