Chi-Ming Che

Che’s seminal research in Reactive Metal-Ligand Multiple Bonded Complexes and d8/d10 metal complexes has led to novel excited state atom transfer catalysis, selective hydrocarbon functionalization reactions, practical phosphorescent and metal-assisted TADF emitters, unique functional supramolecular metal assemblies, and anti-cancer metal medicines for combating metastatic cancers.

1. Synthesis, Reactivities and Structural Studies on High-Valent Ruthenium Oxo Complexes. Ruthenium(IV), Ruthenium(V), and Ruthenium(VI) Oxo Complexes of Tertiary Amine Ligands. C. M. Che,* T. F. Lai, K. Y. Kong, Inorg. Chem. 1987, 26, 2289-2299.
3. Pyrophosphito-Bridged Diplatinum Chemistry. D. M. Roundhill,* H. B. Gray,* C. M. Che*. Acc. Chem. Res. 1989, 22, 55-61.
4. Model Reactions for Nitrogen Fixation. Photo-Induced Formation and X-Ray Crystal Structure of [Os2(NH3)8(CH3CN)2(N2)]5+ from [OsVI(NH3)4N]3+. C.-M. Che, H.-W. Lam, W.-F. Tong, T.-F. Lai, T.-C. Lau. J. Chem. Soc., Chem. Commun. 1989, 1883-1884.
5. Spectroscopy and Redox Properties of the Luminescent Excited State of [Au2(dppm)2]2+ (dppm = Ph2PCH2PPh2). C.-M. Che, H.-W. Lam, W.-F. Tong, T.-F. Lai, T.-C. Lau. J. Chem. Soc., Dalton Trans. 1990, 3215-3219.
6. Photophysical Properties and X-ray Crystal Structure of a Luminescent Platinum(II) Dimer [Pt2(2,2':6,2''-terpyridine)2(Gua)](ClO4)3*H2O (Gua = guanidine anion). H.-K. Yip, C.-M. Che, Z.-Y. Zhou, T. C. W. Mak. J. Chem. Soc. Chem. Commun. 1992, 136-1371.
7. Electroluminescence from triplet metal-ligand charge transfer excited state of transition metal complexes. Y. Ma,* H. Zhang, J. Shen, C.-M. Che. Synth. Met. 1998, 94, 245-248.
8. Dinuclear cyclometallated platinum(II) complex as a sensitive luminescent probe for SDS micelles. L.-Z. Wu, T.-C. Cheung, C.-M. Che,* K.-K. Cheung, M. H. W. Lam. Chem. Commun. 1998, 1127-1128.
9. The Intrinsic 3[ds*ps] Emission of Binuclear Gold(I) Complexes with Two Bridging Diophosphane Ligands Lies in the Near UV: Emissions in the Visible Region are Due to Exciplexes. W.-F. Fu, K.-C. Chan, V. M. Miskowski, C.-M. Che*. Angew. Chem. Int. Ed. 1999, 38, 2783-2785.
10. Resonance Ramen Investigation of Au(I)-Au(I) Interaction of the 1[ds*ps] Excited State of Au2(dcmp)2(ClO4)2 (dcmp = bis(dicyclohexylphosphino)methane). K.-H. Leung, D. L. Phillips,* M.-C. Tse, C.-M. Che,* V. M Miskowski. J. Am. Chem. Soc. 1999, 121, 4799-4803. 
11. Aziridination of Alkenes and Amidation of Alkanes by Bis(tosylimido)-ruthenium(VI) Porphyrins. A Mechanistic Study. S.-M. Au, J.-S. Huang, W.-Y. Yu, W.-H. Fung, C.-M. Che*. J. Am. Chem. Soc. 1999, 121, 9120-9123.
12. Remarkably Stable Iron Porphyrins Bearing Nonheteroatom-Stabilized Carbene or (Alkoxycarbonyl)carbenes: Isolation, X-ray Crystal Structures, and Carbon Atom Transfer Reactions with Hydrocarbons. Y. Li, J.-S. Huang, Z.-Y. Zhou, C.-M. Che,* X.-Z. You. J. Am. Chem. Soc. 2002, 124, 13185-13193.
14. A Practical and Mild Method for Highly Selective Conversion of Terminal Alkenes to Aldehydes via a Subsequent Epoxidation/Isomerization Route Using Ruthenium(IV) Porphyrin Catalysts. J. Chen, C.-M. Che*. Angew. Chem. Int. Ed. 2004, 43, 4950-4954.
15. Platinum(II) Complexes with Dipyridophenazine Ligands as Human Telomerase Inhibitors and Luminescent Probes for G-Quadraplex DNA. D.-L. Ma, C.-M. Che,* S.-C. Yan. J. Am. Chem. Soc. 2009, 131, 1835-1846.
16. Supramolecular Polymers and Chromonic Mesophases Self-Organized from Phosphorescent Cationic Organoplatinum(II) Complexes in Water. W. Lu, Y. Chen, V. A. L. Roy, S. S.-Y. Chui, C.-M. Che*. Angew. Chem. Int. Ed. 2009, 48, 7621-7625.
17. Strongly Luminescent Gold(III) Complexes with Long-Lived Excited States: High Emission Quantum Yields, Energy Up-Conversion and Nonlinear Optical Properties. W.-P. To, K. T. Chan, G. S. M. Tong, C. Ma, W.-M. Kwok, X. Guan, K.-H. Low, C.-M. Che*. Angew. Chem. Int. Ed. 2013, 52, 6648-6652.
18. Nonheme Iron-Mediated Amination of C(sp3)-H Bonds. Quinquepyridine-Supported Iron-Imide/Nitrene Intermediates by Experimental Studies and DFT Calculations. Y. Liu, X. Guan, E. L.-M. Wong, P. Liu, J.-S. Huang, C.-M. Che*. J. Am. Chem. Soc. 2013, 135, 7194-7204.
19. Strongly Phosphorescent Palladium(II) Complexes of Tetradentate Ligands with Mixed Oxygen, Carbon, and Nitrogen Donor Atoms: Photophysics, Photochemistry, and Applications. P.-K. Chow, C. Ma, W.-P. To, G. S. M. Tong, S.-L. Lai, S. C. F. Kui, W.-M. Kwok, C.-M. Che*. Angew. Chem. Int. Ed. 2013, 52, 11775-11779.
20. Highly Phosphorescent Platinum(II) Emitters: Photophysics, Materials and Biological Applications. K. Li, G. S. M. Tong, Q. Wan, G. Cheng, W.-Y. Tong, W.-H. Ang, W.-L. Kwong, C.-M. Che*. Chem. Sci. 2016, 7, 1653-1673.
21. Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selective probe mismatched and abasic DNA. S. K. Fung, T. Zou, B. Cao, T. Chen, W.-P. To, C. Yang, C.-N. Lok, C.-M. Che*. Nat. Commun. 2016, 7, 10655.
22. Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60. D. Hu, Y. Liu, Y.-T. Lai, K.-C. Tong, Y.-M. Fung, C.-N. Lok, C.-M. Che*. Angew. Chem. Int. Ed. 2017, 56, 3892-3896.
23.  Cyclometalated Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands Engage Multiple Anti-Cancer Molecular Targets. S. K. Fung, T. Zou, B. Cao, P.-Y. Lee, Y. M. E. Fung, D. Hu, C.-N. Lok, C.-M. Che*. Angew. Chem. Int. Ed. 2017, 56, 3892-3896.
24.  Highly Luminescent Pincer Gold(III) Alkyl Emitters: Thermally Activated Delayed Fluorescence and Solution-Processed OLEDs. W.-P. To, D. ZHou, G. S. M. Tong, G. Cheng, C. Yang, C.-M. Che*. Angew. Chem. Int. Ed. 2017, 56, 14036-14041.
24. N-Heterocyclic Carbene Iron(III) Porphyrin-Catalyzed Intramolecular C(sp3)-H Amination of Akyl Azides. K.-P. Shing, Y. Liu, B. Cao, X.-Y. Chang, T. You, C.-M. Che*. Angew. Chem. Int. Ed. 2018, 57, 3089-3093.
25.  Ruthenium(II) Porphyrin Quinoid Carbene Complexes: Synthesis, Crystal Structure, and Reactivity toward Carbene Transfer and Hydrogen Atom Transfer Reactions. H.-X. Wang, Q. Wan, K. Wu, K.-H. Low, C. Yang, C.-Y. Zhou, J.-S. Huang, C.-M. Che*. J. Am. Chem. Soc. 2019, 141, 9027-9046.
26. Controlled Synthesis of PdII and PtII Supramolecular Copolymer with Sequential Multiblock and Amplified Phosphorescence. Q. Wan, W.-P. To, X. Chang, C.-M. Che*. Chem 2020, 6, 945-967.
27. An anticancer gold(III)-activated porphyrin scaffold that covalently modifies protein cysteine thiols. K.-C. Tong, C.-N. Lok, P.-K. Wan, D. Hu, Y. M. E. Fung, X.-Y. Chang, S. Huang, H. Jiang, C.-M. Che*. PNAS 2020, 117, 13321-1329.
28. Iron-Catalyzed Highly Enantioselective cis-Dihydroxylation of Trisubstituted Alkenes with Aqueous H2O2. J. Wei, L. Wu, H.-X. Wang, X. Zhang, C.-W. Tse, C.-Y. Zhou, J.-S. Huang, C.-M. Che*. Angew. Chem. Int. Ed. 2020, 59, 16561-16571.
29. Strong metal-metal Pauli repulsion leads to repulsive metallophilicity in closed-shell d8 and d10 organometallic complexes. Q. Wan,* J. Yang,* W.-P. To, C.-M. Che*. PNAS 2021, 118, e2019265118.
30. Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth. P.-K. Wan, K.-C. Tong, C.-N. Lok, C. Zhang, X.-Y. Chang, K.-H. Sze, A. S. T. Wong, C.-M. Che*. PNAS 2021, 118, e2025806118.
31. Optical Signal Modulation in Photonic Waveguiding Heteroarchitectures with Continuously Variable Visible-To-Near-Infrared Emission Color. Q. Wan, K. Xiao, Z. Li, J. Yang, J. T Kim, X. Cui, C.-M. Che*. Adv. Mater. 2022, 34, 2204839.
32. Chiral Iron Porphyrins Catalyze Enantioselective Intramolecular C(sp3)-H Bond Amination Upon Visible-Light Irradiation. H.-H. Wang, H. Shao, G. Huang, J. Fan, W.-P. To, L. Dang, Y. Liu, C.-M. Che*. Angew. Chem. Int. Ed. 2023, 62, e202218577.
33. Sterically Hindered Tetradentate [Pt(O^N^C^N)] Emitters with Radiative Decay Rates up to 5.3 x 105 s-1 for Phosphorescent Organic Light-Emitting Diodes with LT95 Lifetime over 9200 h at 1000 cd m-2. T.-L. Lam, H. Li, K. Tan, Z. Chen, Y.-K. Tang, J. Yang, G. Cheng,* L. Dai,* C.-M. Che.* Small 2024, 20, 307393.

1. 3rd Class Prize of State Natural Science Award of China (1994)
2. Elected to Academician of Chinese Academy of Sciences, China (1995)
3. Croucher Senior Fellowship Award from the Croucher Foundation of Hong Kong (1997) 
4. National Outstanding Young Scholar Award from The National Science Foundation of China (2000)
5. Distinguished Research Achievement Award honored by The University of Hong Kong (2000)
6. Federation of Asian Chemical Societies (FACS) Foundation Lectureship Award (2003)
7. TWAS Prize in Chemistry (2006)
8. 1st Class Prize of State Natural Science Award of China (2006)
9. Elected to Fellow of The World Academy of Sciences (2007)
10. Seaborg Lectureship at University of California at Berkeley (2007)
11. Julia S. and Edward C. Lee Lectureship at University of Chicago (2008)
12. Leader of the Year 2007 Prize by the Hong Kong SAR (2008)
13. Centenary Prize from the Royal Society of Chemistry (2013)
14. Elected to Foreign Associate (renamed as International Member in 2020) of National Academy of Sciences, USA (2013)
15. Davison Lectureship at Massachusetts Institute of Technology (2013-2014)
16. Bronze Bauhinia Star from the HKSAR Government (2014)
Elected to Founding Member of The Academy of Sciences of Hong Kong (2015)
17. Huang Yao-Zeng Organometallic Chemistry Award of the Chinese Chemical Society - Lifetime Achievement Award (2016)
18. Ryoji Noyori ACES Award (2016)
19. First Class Award of Shenzhen Municipal Natural Science Award (2019)
20. Luigi Sacconi Medal (2020)
21. Silver Bauhinia Star from the HKSAR Government (2021)
22. Research.com (2022) ranked 65th globally, 5th in China in Chemistry and H-index (Web of Science): 131